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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:27292
Term: vinyl carbamate
Definition: A carbamate ester that has formula C3H5NO2.
Chemical ID: MESH:C017963
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1affects metabolic processingEXP 6480464CTDCYP2E1 protein affects the metabolism of vinyl carbamatePMID:11181492
CYP2E1increases oxidationEXP 6480464CTDCYP2E1 protein results in increased oxidation of vinyl carbamatePMID:1664256
CYP2E1multiple interactionsEXP 6480464CTD[vinyl carbamate co-treated with NADP] inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]PMID:11181492
CYP2E1affects metabolic processingISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein affects the metabolism of vinyl carbamatePMID:11181492
CYP2E1affects oxidationISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein affects the oxidation of vinyl carbamatePMID:20205516
CYP2E1affects oxidationISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein affects the oxidation of vinyl carbamatePMID:17296623
CYP2E1decreases activityISOCyp2e1 (Mus musculus)6480464CTDvinyl carbamate results in decreased activity of CYP2E1 proteinPMID:11134547
CYP2E1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDvinyl carbamate results in decreased expression of CYP2E1 proteinPMID:11134547
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[diallyl sulfone results in decreased activity of CYP2E1 protein] which affects the susceptibility to vinyl carbamate; diallyl sulfone inhibits the reaction [CYP2E1 protein affects the oxidation of vinyl carbamate]PMID:17341656 PMID:20205516
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTDdiallyl sulfone inhibits the reaction [CYP2E1 protein affects the oxidation of vinyl carbamate]PMID:17296623
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