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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550475
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Acc ID: CHEBI:27214
Term: uranium atom
Definition: An actinoid atom that has formula U.
Chemical ID: MESH:D014501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp27a1decreases activityISOCyp27a1 (Rattus norvegicus)6480464CTDUranium results in decreased activity of CYP27A1 proteinPMID:16502312
Cyp27a1decreases expressionISOCyp27a1 (Rattus norvegicus)6480464CTDUranium results in decreased expression of CYP27A1 mRNAPMID:17118558
Cyp27a1increases activityISOCyp27a1 (Rattus norvegicus)6480464CTDUranium results in increased activity of CYP27A1 proteinPMID:16231126 PMID:16502312
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