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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:2710
Term: androst-5-ene-3beta,17beta-diol
Definition: A 3beta-hydroxy-Delta(5)-steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.
Chemical ID: MESH:D015114
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2multiple interactionsEXP 6480464CTDAndrostenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]PMID:9048584
Esr2increases expressionISOEsr2 (Mus musculus)6480464CTDAndrostenediol results in increased expression of ESR2 proteinPMID:27634370
Esr2multiple interactionsISOEsr2 (Mus musculus)6480464CTDESR2 protein alternative form inhibits the reaction [Androstenediol results in increased expression of ESR2 protein]PMID:27634370
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