GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkcd | decreases response to substance | ISO | Prkcd (Mus musculus) | 6480464 | CTD | PRKCD gene mutant form results in decreased susceptibility to tributyltin | PMID:25895139 | Prkcd | multiple interactions | ISO | Prkcd (Mus musculus) | 6480464 | CTD | PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BAD protein modified form]; PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2L1 protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of BAX protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; PRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]; PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]; PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA] | PMID:25895139 | | ||||||||||||||||||||||
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