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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551496
Species: Mus musculus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Acc ID: CHEBI:2700
Term: anandamide
Definition: An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.
Chemical ID: MESH:C078814
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2decreases expressionISOABCG2 (Homo sapiens)6480464CTDanandamide results in decreased expression of ABCG2 mRNA; anandamide results in decreased expression of ABCG2 proteinPMID:30610963
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in decreased expression of ABCG2 mRNA]; anandamide affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA]; anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]; iodopravadoline inhibits the reaction [anandamide results in decreased expression of ABCG2 mRNA]PMID:30610963 PMID:34756920
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