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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:2687
Term: amsacrine
Definition: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Chemical ID: MESH:D000677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2aaffects response to substanceISOTOP2A (Homo sapiens)6480464CTDTOP2A protein modified form affects the susceptibility to AmsacrinePMID:12569090
Top2adecreases response to substanceISOTOP2A (Homo sapiens)6480464CTDTOP2A gene mutant form results in decreased susceptibility to Amsacrine; TOP2A protein mutant form results in decreased susceptibility to AmsacrinePMID:10727526 PMID:11470519 PMID:11676865 PMID:1651812
Top2amultiple interactionsISOTOP2A (Homo sapiens)6480464CTD[EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine; [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to AmsacrinePMID:16969495 PMID:21878638
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