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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564788
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wrn
Name: WRN RecQ like helicase
Acc ID: CHEBI:2687
Term: amsacrine
Definition: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Chemical ID: MESH:D000677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wrnincreases response to substanceISOWRN (Homo sapiens)6480464CTDWRN gene mutant form results in increased susceptibility to AmsacrinePMID:10725663
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