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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:2687
Term: amsacrine
Definition: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Chemical ID: MESH:D000677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTD[EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine

PMID:16969495
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.