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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:2682
Term: amphotericin B
Definition: A macrolide antibiotic used to treat potentially life-threatening fungal infections.
Chemical ID: MESH:D000666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases activityISOHIF1A (Homo sapiens)6480464CTDAmphotericin B results in decreased activity of HIF1A proteinPMID:16189267
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDAmphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]PMID:16189267
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