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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1decreases response to substanceEXP 6480464CTDSOD1 protein results in decreased susceptibility to AmphetaminePMID:11731100
SOD1multiple interactionsEXP 6480464CTDSOD1 protein inhibits the reaction [Amphetamine results in decreased expression of SLC6A3 protein]PMID:11731100
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDAmphetamine results in increased expression of SOD1 mRNAPMID:16084549 PMID:30779732
SOD1multiple interactionsISOSod1 (Mus musculus)6480464CTDSOD1 protein inhibits the reaction [Amphetamine results in decreased expression of SLC18A2 protein]PMID:11731100
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDFOS protein promotes the reaction [Amphetamine results in increased expression of SOD1 mRNA]; JUN protein promotes the reaction [Amphetamine results in increased expression of SOD1 mRNA]PMID:16084549
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