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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62346
Species: Mus musculus
RGD Object: Gene
Symbol: Pdyn
Name: prodynorphin
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdynincreases expressionEXP 6480464CTDAmphetamine results in increased expression of PDYN mRNAPMID:12700712
Pdynmultiple interactionsEXP 6480464CTDADORA2A protein affects the reaction [Amphetamine results in increased expression of PDYN mRNA]PMID:12700712
Pdynincreases expressionISOPdyn (Rattus norvegicus)6480464CTDAmphetamine results in increased expression of PDYN mRNAPMID:14521997 PMID:15033416 PMID:15592348
Pdynmultiple interactionsISOPdyn (Rattus norvegicus)6480464CTDBaclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]; CTAP octapeptide inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]; tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]PMID:14521997 PMID:15033416 PMID:15592348
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