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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:2672
Term: Ammothamnine
Definition: An alkaloid that has formula C15H24N2O2.
Chemical ID: MESH:C037573
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDoxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]PMID:23568217 PMID:35290143
Reladecreases expressionISORela (Mus musculus)6480464CTDoxymatrine results in decreased expression of RELA proteinPMID:37196756
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDoxymatrine analog inhibits the reaction [TNF protein results in increased expression of RELA protein modified form]PMID:34459104
Relamultiple interactionsISORela (Mus musculus)6480464CTDNFE2L2 protein promotes the reaction [oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]PMID:37196756
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