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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:26710
Term: sodium chloride
Definition: An inorganic chloride salt having sodium(1+) as the counterion.
Chemical ID: MESH:D012965
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1multiple interactionsEXP 6480464CTD[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein; [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein; [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]PMID:17616752 PMID:22431579
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