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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621393
Species: Mus musculus
RGD Object: Gene
Symbol: Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Acc ID: CHEBI:26708
Term: sodium atom
Definition: An alkali metal atom that has formula Na.
Chemical ID: MESH:D012964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn2aincreases transportISOScn2a (Rattus norvegicus)6480464CTDSCN2A protein mutant form results in increased transport of Sodium; SCN2A protein results in increased transport of SodiumPMID:19442819
Scn2amultiple interactionsISOScn2a (Rattus norvegicus)6480464CTD2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]; [SCN2A protein binds to SCN1B protein] which affects the transport of Sodium; [SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium; [SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium; cyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]; cypermethrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]; decamethrin affects the reaction [SCN2A protein mutant form results in increased transport of Sodium]; decamethrin affects the reaction [SCN2A protein results in increased transport of Sodium]; fenpropathrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]; fenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]PMID:18538810 PMID:19026681 PMID:19442819 PMID:9236205
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