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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736946
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB4
Name: ATP binding cassette subfamily B member 4
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB4decreases expressionISOAbcb4 (Rattus norvegicus)6480464CTDAmiodarone results in decreased expression of ABCB4 mRNAPMID:27765674
ABCB4increases expressionISOAbcb4 (Mus musculus)6480464CTDAmiodarone results in increased expression of ABCB4 mRNAPMID:24489787
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