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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733712
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF4
Name: activating transcription factor 4
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF4decreases expressionEXP 6480464CTDAmiodarone results in decreased expression of ATF4 mRNAPMID:35641671
ATF4increases expressionEXP 6480464CTDAmiodarone results in increased expression of ATF4 mRNA; Amiodarone results in increased expression of ATF4 proteinPMID:21292685 PMID:36586010
ATF4increases expressionISOAtf4 (Mus musculus)6480464CTDAmiodarone results in increased expression of ATF4 mRNAPMID:28962527 PMID:34259586
ATF4multiple interactionsISOAtf4 (Mus musculus)6480464CTD1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of ATF4 mRNA]PMID:28962527 PMID:34259586
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