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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732638
Species: Mus musculus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparaincreases expressionEXP 6480464CTDAmiodarone results in increased expression of PPARA mRNAPMID:24489787 PMID:30685923
Pparaincreases response to substanceEXP 6480464CTDPPARA protein results in increased susceptibility to AmiodaronePMID:15265979
Pparadecreases expressionISOPpara (Rattus norvegicus)6480464CTDAmiodarone results in decreased expression of PPARA mRNAPMID:32084307
Pparaincreases expressionISOPpara (Rattus norvegicus)6480464CTDAmiodarone results in increased expression of PPARA mRNAPMID:19224547
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