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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDAmiodarone results in decreased phosphorylation of MAPK1 proteinPMID:26515726
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAmiodarone results in decreased phosphorylation of MAPK1 proteinPMID:26515726
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDAmiodarone results in increased phosphorylation of MAPK1 proteinPMID:34590760
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAmiodarone results in increased phosphorylation of MAPK1 proteinPMID:31071512
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTD[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Vitamin D inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]PMID:34590760
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