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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDAmiodarone results in decreased expression of PPARG mRNAPMID:35641671
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDAmiodarone results in increased expression of PPARG mRNAPMID:21123845
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of FADS2 mRNA]; [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of SCD mRNA]; [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine]; Amiodarone binds to and results in increased activity of PPARG proteinPMID:21123845 PMID:24489787
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