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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9multiple interactionsEXP 6480464CTD[Amiodarone co-treated with TNF protein] results in increased activity of CASP9 proteinPMID:23042730
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDAmiodarone results in increased expression of CASP9 mRNAPMID:19774075
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[TNFSF10 co-treated with Amiodarone] results in increased cleavage of CASP9 proteinPMID:21292685
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