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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3224
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a1
Name: solute carrier family 22 member 1
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a1affects expressionEXP 6480464CTDAmiodarone affects the expression of SLC22A1 mRNAPMID:19483382
Slc22a1multiple interactionsISOSLC22A1 (Homo sapiens)6480464CTDAmiodarone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]PMID:21641380
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