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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3070
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnajb9
Name: DnaJ heat shock protein family (Hsp40) member B9
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7374766480464CTDAmiodarone results in increased expression of DNAJB9 mRNA

PMID:19774075
increases expressionISORGD:7374776480464CTDAmiodarone results in increased expression of DNAJB9 mRNA, Amiodarone results in increased expression of DNAJB9 protein

PMID:28962527
multiple interactionsISORGD:7374776480464CTD1-(3, 4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA], 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA], DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]

PMID:28962527
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.