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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDAmiodarone results in decreased expression of BCL2 proteinPMID:21224497
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDAmiodarone results in decreased expression of BCL2 mRNA; Amiodarone results in decreased expression of BCL2 proteinPMID:34434487
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[3-methyladenine co-treated with Amiodarone] results in decreased expression of BCL2 protein; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]]PMID:23912912 PMID:34434487
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