GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | EXP | | 6480464 | CTD | Amiodarone results in decreased expression of EGFR mRNA | PMID:24535564 | Egfr | decreases phosphorylation | EXP | | 6480464 | CTD | Amiodarone results in decreased phosphorylation of EGFR protein | PMID:26515726 | Egfr | multiple interactions | EXP | | 6480464 | CTD | Amiodarone affects the reaction [VCAN protein alternative form affects the phosphorylation of EGFR protein] | PMID:26515726 | Egfr | decreases phosphorylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Amiodarone results in decreased phosphorylation of EGFR protein | PMID:26515726 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]] | PMID:26515726 | |
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