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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDAmiodarone results in decreased activity of CYP1A1 proteinPMID:33814510 PMID:34181028
Cyp1a1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDAmiodarone results in increased expression of CYP1A1 mRNAPMID:19224547 PMID:32084307
Cyp1a1increases response to substanceISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased susceptibility to AmiodaronePMID:26477383
Cyp1a1multiple interactionsISOCyp1a1 (Rattus norvegicus)6480464CTDAmiodarone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]PMID:20362646
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