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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62335
Species: Mus musculus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xdhincreases chemical synthesisEXP 6480464CTDXDH protein results in increased chemical synthesis of Reactive Oxygen SpeciesPMID:7695923
Xdhmultiple interactionsEXP 6480464CTD[XDH protein results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of IL1B mRNA; [XDH protein results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of TNF mRNAPMID:7695923
Xdhincreases abundanceISOXdh (Rattus norvegicus)6480464CTDXDH protein alternative form results in increased abundance of Reactive Oxygen SpeciesPMID:9789800
Xdhmultiple interactionsISOXDH (Homo sapiens)6480464CTDXDH protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]PMID:19158351
Xdhmultiple interactionsISOXdh (Rattus norvegicus)6480464CTDDesoxycorticosterone promotes the reaction [XDH protein results in increased chemical synthesis of Reactive Oxygen Species]; Isoflurophate promotes the reaction [XDH protein alternative form results in increased abundance of Reactive Oxygen Species]PMID:16271043 PMID:9789800
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