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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects chemical synthesisEXP 6480464CTDCYP2E1 protein affects the chemical synthesis of Reactive Oxygen SpeciesPMID:14693714
Cyp2e1decreases response to substanceEXP 6480464CTDCYP2E1 protein results in decreased susceptibility to Reactive Oxygen SpeciesPMID:12470497
Cyp2e1increases chemical synthesisISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased chemical synthesis of Reactive Oxygen SpeciesPMID:10498651
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen SpeciesPMID:25601990
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species; [Ethanol co-treated with CYP2E1 protein] results in increased abundance of Reactive Oxygen Species; fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]PMID:18845238 PMID:22222162
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