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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDReactive Oxygen Species results in increased expression of BAX proteinPMID:26884717
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDReactive Oxygen Species results in increased expression of BAX proteinPMID:26884717
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCyclosporine inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]PMID:26884717
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]PMID:26884717
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