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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353417
Species: Homo sapiens
RGD Object: Gene
Symbol: XIAP
Name: X-linked inhibitor of apoptosis
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XIAPmultiple interactionsEXP 6480464CTD[[Bortezomib co-treated with Butyrates] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein; [[Bortezomib co-treated with vorinostat] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein; [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein; [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP proteinPMID:15173093 PMID:17136320 PMID:23660334
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