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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349866
Species: Homo sapiens
RGD Object: Gene
Symbol: KLK1
Name: kallikrein 1
Acc ID: CHEBI:2639
Term: amiloride
Definition: A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Chemical ID: MESH:D000584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLK1increases response to substanceISOKlk1 (Mus musculus)6480464CTDKLK1 protein results in increased susceptibility to AmiloridePMID:18086683
KLK1multiple interactionsISOKlk1 (Mus musculus)6480464CTDKLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]PMID:18086683
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