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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11269
Species: Mus musculus
RGD Object: Gene
Symbol: Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Acc ID: CHEBI:2639
Term: amiloride
Definition: A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Chemical ID: MESH:D000584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scnn1aaffects activityEXP 6480464CTDAmiloride affects the activity of SCNN1A proteinPMID:8617496
Scnn1amultiple interactionsISOScnn1a (Rattus norvegicus)6480464CTD[farglitazar co-treated with Amiloride] results in increased expression of SCNN1A mRNAPMID:15475592
Scnn1amultiple interactionsISOSCNN1A (Homo sapiens)6480464CTDAmiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]PMID:18398334 PMID:18665318 PMID:19359370
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