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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731890
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:2636
Term: amifostine
Definition: An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Chemical ID: MESH:D004999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1decreases phosphorylationISOCDK1 (Homo sapiens)6480464CTDAmifostine results in decreased phosphorylation of CDK1 proteinPMID:16628227
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTDolomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]PMID:16628227
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