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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:2636
Term: amifostine
Definition: An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Chemical ID: MESH:D004999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAincreases localizationEXP 6480464CTDAmifostine results in increased localization of RELA proteinPMID:10590050
RELAmultiple interactionsEXP 6480464CTDAmifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]PMID:19010997
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