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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69220
Species: Homo sapiens
RGD Object: Gene
Symbol: ALDH2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:25879
Term: pentaerythritol tetranitrate
Definition: A pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex.
Chemical ID: MESH:D010417
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALDH2increases metabolic processingISOAldh2 (Mus musculus)6480464CTDALDH2 protein results in increased metabolism of Pentaerythritol TetranitratePMID:21156756
ALDH2increases response to substanceISOAldh2 (Mus musculus)6480464CTDALDH2 protein results in increased susceptibility to Pentaerythritol TetranitratePMID:21156756
ALDH2multiple interactionsISOAldh2 (Mus musculus)6480464CTD[ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide; [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrolPMID:21156756
ALDH2multiple interactionsISOAldh2 (Rattus norvegicus)6480464CTDALDH2 protein affects the metabolism of and results in increased activity of Pentaerythritol TetranitratePMID:15331769
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