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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:25858
Term: 1,7-dimethylxanthine
Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.
Chemical ID: MESH:C021183
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of 1,7-dimethylxanthinePMID:1302044
Cyp1a2increases chemical synthesisISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased chemical synthesis of 1,7-dimethylxanthinePMID:1302044
Cyp1a2increases hydroxylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased hydroxylation of 1,7-dimethylxanthinePMID:15980104
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of 1,7-dimethylxanthinePMID:19215233
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 1-methylxanthine; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthinePMID:19215233 PMID:31132250
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