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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3increases expressionISOStat3 (Mus musculus)6480464CTDOzone results in increased expression of STAT3 mRNAPMID:26342085
STAT3increases phosphorylationISOStat3 (Mus musculus)6480464CTDOzone results in increased phosphorylation of STAT3 proteinPMID:20826374 PMID:26342085
STAT3multiple interactionsISOStat3 (Mus musculus)6480464CTD[Ovalbumin co-treated with Ozone] results in increased expression of and results in increased phosphorylation of STAT3 protein; [SFTPA2 protein co-treated with Ozone] results in increased expression of STAT3 mRNAPMID:29202868 PMID:34760922
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