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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736378
Species: Homo sapiens
RGD Object: Gene
Symbol: APOE
Name: apolipoprotein E
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOEdecreases expressionISOApoe (Mus musculus)6480464CTDOzone results in decreased expression of APOE mRNAPMID:12763052
APOEmultiple interactionsISOApoe (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of APOE mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of APOE mRNAPMID:34911549
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