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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPmultiple interactionsEXP 6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of APP mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of APP mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of and results in increased oxidation of APP mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased expression of and results in increased oxidation of APP mRNAPMID:32699268 PMID:32845096
APPincreases expressionISOApp (Mus musculus)6480464CTDOzone results in increased expression of APP proteinPMID:29385576
APPincreases response to substanceISOApp (Mus musculus)6480464CTDAPP results in increased susceptibility to OzonePMID:26116027
APPmultiple interactionsISOApp (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of APP mRNAPMID:27106289 PMID:34911549
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