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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pleasant odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDGSTM1 gene polymorphism promotes the reaction [NQO1 gene SNP results in increased susceptibility to Ozone], NQO1 protein affects the reaction [Ozone results in increased metabolism of F2-Isoprostanes], NQO1 protein promotes the reaction [Ozone results in increased expression of CXCL8 mRNA]

PMID:17652311, PMID:19059883
increases response to substanceISORGD:104736480464CTDNQO1 protein results in increased susceptibility to Ozone

PMID:19059883
multiple interactionsISORGD:104736480464CTDNQO1 protein promotes the reaction [Ozone results in increased expression of CXCL1 protein]

PMID:19059883
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.