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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735247
Species: Homo sapiens
RGD Object: Gene
Symbol: SCGB1A1
Name: secretoglobin family 1A member 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SCGB1A1affects secretionISOScgb1a1 (Rattus norvegicus)6480464CTDOzone affects the secretion of SCGB1A1 proteinPMID:10486303
SCGB1A1decreases expressionISOScgb1a1 (Mus musculus)6480464CTDOzone results in decreased expression of SCGB1A1 mRNA; Ozone results in decreased expression of SCGB1A1 proteinPMID:14515223
SCGB1A1increases expressionISOScgb1a1 (Mus musculus)6480464CTDOzone results in increased expression of SCGB1A1 proteinPMID:14515223
SCGB1A1increases expressionISOScgb1a1 (Rattus norvegicus)6480464CTDOzone results in increased expression of SCGB1A1 mRNA; Ozone results in increased expression of SCGB1A1 proteinPMID:9028799
SCGB1A1increases response to substanceISOScgb1a1 (Mus musculus)6480464CTDSCGB1A1 gene mutant form results in increased susceptibility to OzonePMID:16226776
SCGB1A1increases secretionISOScgb1a1 (Mus musculus)6480464CTDOzone results in increased secretion of SCGB1A1 proteinPMID:14515223
SCGB1A1multiple interactionsISOScgb1a1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of SCGB1A1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of SCGB1A1 mRNA; SCGB1A1 protein affects the reaction [Ozone results in increased expression of CCL11 mRNA]; SCGB1A1 protein affects the reaction [Ozone results in increased expression of CCL3 mRNA]; SCGB1A1 protein affects the reaction [Ozone results in increased expression of CXCL2 mRNA]; SCGB1A1 protein affects the reaction [Ozone results in increased expression of IL6 mRNA]; SCGB1A1 protein affects the reaction [Ozone results in increased expression of MT1 mRNA]PMID:10027076 PMID:34911549 PMID:9700096
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