GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr2 | increases expression | EXP | | 6480464 | CTD | Ozone results in increased expression of TLR2 mRNA | PMID:33383130 | Tlr2 | decreases expression | ISO | Tlr2 (Mus musculus) | 6480464 | CTD | Ozone results in decreased expression of TLR2 mRNA | PMID:26342085 | Tlr2 | decreases response to substance | ISO | Tlr2 (Mus musculus) | 6480464 | CTD | TLR2 gene mutant form results in decreased susceptibility to Ozone | PMID:17626835 | Tlr2 | increases expression | ISO | Tlr2 (Mus musculus) | 6480464 | CTD | Ozone results in increased expression of TLR2 mRNA | PMID:17626835 | Tlr2 | multiple interactions | ISO | Tlr2 (Mus musculus) | 6480464 | CTD | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TLR2 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of TLR2 mRNA; [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of TLR2 mRNA; TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 protein] | PMID:16864405 PMID:17626835 PMID:25658374 PMID:34911549 | | ||||||||||||||||||||||
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