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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bincreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDOzone results in increased phosphorylation of GSK3B proteinPMID:33146391
Gsk3bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in increased expression of GSK3B mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased phosphorylation of GSK3B protein; [Coconut Oil co-treated with Ozone] results in decreased expression of GSK3B mRNAPMID:33217375 PMID:34790285 PMID:37088303
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD[Air Pollutants results in increased abundance of Ozone] which affects the expression of GSK3B mRNAPMID:35430440
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