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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733179
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNB1
Name: cyclin B1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNB1multiple interactionsEXP 6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CCNB1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CCNB1 mRNA; [Oxygen co-treated with Ozone] results in decreased expression of CCNB1 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of CCNB1 mRNA; Cannabidiol promotes the reaction [[Oxygen co-treated with Ozone] results in decreased expression of CCNB1 mRNA]PMID:32699268 PMID:32992648
CCNB1decreases expressionISOCcnb1 (Mus musculus)6480464CTDOzone results in decreased expression of CCNB1 mRNA; Ozone results in decreased expression of CCNB1 proteinPMID:16183385
CCNB1increases expressionISOCcnb1 (Mus musculus)6480464CTDOzone results in increased expression of CCNB1 mRNAPMID:25658374
CCNB1multiple interactionsISOCcnb1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of CCNB1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CCNB1 mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which affects the expression of CCNB1 mRNA; TTPA protein affects the reaction [Ozone results in increased expression of CCNB1 mRNA]PMID:19555225 PMID:25658374 PMID:27106289 PMID:34911549
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