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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1multiple interactionsEXP 6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NR3C1 mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of NR3C1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of NR3C1 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of NR3C1 mRNAPMID:32699268 PMID:32845096
NR3C1decreases expressionISONr3c1 (Mus musculus)6480464CTDOzone results in decreased expression of NR3C1 proteinPMID:27380433 PMID:28279894
NR3C1decreases expressionISONr3c1 (Rattus norvegicus)6480464CTDOzone results in decreased expression of NR3C1 mRNAPMID:26667334 PMID:35737395
NR3C1increases expressionISONr3c1 (Rattus norvegicus)6480464CTDOzone results in increased expression of NR3C1 mRNAPMID:34051339
NR3C1multiple interactionsISONr3c1 (Mus musculus)6480464CTD[Ovalbumin co-treated with Ozone] results in increased expression of NR3C1 mRNA; IL17A protein promotes the reaction [Ozone results in decreased expression of NR3C1 protein]; Ozone promotes the reaction [Ovalbumin results in increased expression of and results in decreased phosphorylation of NR3C1 protein]; Progesterone inhibits the reaction [Ozone results in decreased expression of NR3C1 protein]PMID:27380433 PMID:28279894 PMID:34760922
NR3C1multiple interactionsISONr3c1 (Rattus norvegicus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of NR3C1 mRNAPMID:37047376
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