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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730899
Species: Mus musculus
RGD Object: Gene
Symbol: Ereg
Name: epiregulin
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eregincreases expressionEXP 6480464CTDOzone results in increased expression of EREG mRNAPMID:25658374
Eregmultiple interactionsEXP 6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of EREG mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of EREG mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of EREG mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of EREG mRNAPMID:25658374 PMID:27106289 PMID:34911549
Eregincreases expressionISOEreg (Rattus norvegicus)6480464CTDOzone results in increased expression of EREG mRNAPMID:16716893
Eregmultiple interactionsISOEREG (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of EREG mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of EREG mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of EREG mRNAPMID:32699268
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