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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pde5a
Name: phosphodiesterase 5A
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pde5amultiple interactionsISOPde5a (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PDE5A mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PDE5A mRNAPMID:34911549
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