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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl4
Name: C-C motif chemokine ligand 4
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl4decreases expressionISOCcl4 (Mus musculus)6480464CTDOzone results in decreased expression of CCL4 mRNAPMID:26342085
Ccl4increases expressionISOCCL4 (Homo sapiens)6480464CTDOzone results in increased expression of CCL4 mRNAPMID:31476115
Ccl4increases expressionISOCcl4 (Mus musculus)6480464CTDOzone results in increased expression of CCL4 proteinPMID:27679563
Ccl4multiple interactionsISOCCL4 (Homo sapiens)6480464CTD[Aripiprazole co-treated with Ozone] results in increased expression of CCL4 mRNAPMID:31476115
Ccl4multiple interactionsISOCcl4 (Mus musculus)6480464CTD[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein; IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein]; Ozone inhibits the reaction [[[Industrial Waste results in increased abundance of Water Pollutants] which co-treated with naphthenic acid] results in decreased expression of CCL4 mRNA]PMID:21940034 PMID:27472835
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