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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fdft1decreases expressionEXP 6480464CTDOzone results in decreased expression of FDFT1 mRNAPMID:16716893
Fdft1multiple interactionsISOFdft1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of FDFT1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of FDFT1 mRNAPMID:27106289 PMID:34911549
Fdft1multiple interactionsISOFDFT1 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] affects the expression of and affects the oxidation of FDFT1 mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of FDFT1 protein; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of and results in increased oxidation of FDFT1 mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of FDFT1 protein; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which affects the expression of and affects the oxidation of FDFT1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of FDFT1 protein; [Volatile Organic Compounds co-treated with Ozone] affects the expression of and affects the oxidation of FDFT1 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of FDFT1 proteinPMID:32699268 PMID:32845096
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