Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3870
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tlr4
Name:	toll-like receptor 4

Acc ID:	CHEBI:25812
Term:	ozone
Definition:	An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID:	MESH:D010126

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tlr4	increases expression	EXP		6480464	CTD	Ozone results in increased expression of TLR4 mRNA	PMID:33383130
Tlr4	multiple interactions	EXP		6480464	CTD	[Coconut Oil co-treated with Ozone] results in decreased expression of TLR4 mRNA	PMID:33217375
Tlr4	affects expression	ISO	TLR4 (Homo sapiens)	6480464	CTD	Ozone affects the expression of TLR4 mRNA	PMID:23665308
Tlr4	affects response to substance	ISO	Tlr4 (Mus musculus)	6480464	CTD	TLR4 protein affects the susceptibility to Ozone	PMID:22300504
Tlr4	decreases expression	ISO	Tlr4 (Mus musculus)	6480464	CTD	Ozone results in decreased expression of TLR4 mRNA mutant form	PMID:11159012
Tlr4	decreases response to substance	ISO	Tlr4 (Mus musculus)	6480464	CTD	TLR4 gene mutant form results in decreased susceptibility to Ozone; TLR4 protein mutant form results in decreased susceptibility to Ozone	PMID:11159012 PMID:17626835
Tlr4	increases expression	ISO	TLR4 (Homo sapiens)	6480464	CTD	Ozone results in increased expression of TLR4 mRNA	PMID:27325435
Tlr4	increases expression	ISO	Tlr4 (Mus musculus)	6480464	CTD	Ozone results in increased expression of TLR4 mRNA	PMID:11159012 PMID:16864405 PMID:17626835 PMID:21543283
Tlr4	increases response to substance	ISO	Tlr4 (Mus musculus)	6480464	CTD	TLR4 protein results in increased susceptibility to Ozone; TLR4 results in increased susceptibility to Ozone	PMID:11159012 PMID:21543283
Tlr4	multiple interactions	ISO	TLR4 (Homo sapiens)	6480464	CTD	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of TLR4 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of TLR4 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of TLR4 mRNA	PMID:32699268
Tlr4	multiple interactions	ISO	Tlr4 (Mus musculus)	6480464	CTD	[Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR4 mRNA; TLR4 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; TLR4 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 protein]; TLR4 protein affects the reaction [Ozone results in increased expression of NOS2 mRNA]	PMID:11159012 PMID:16864405 PMID:17626835

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