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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3243
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2rx6
Name: purinergic receptor P2X 6
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2rx6decreases expressionISOP2rx6 (Mus musculus)6480464CTDOzone results in decreased expression of P2RX6 mRNAPMID:33026818
P2rx6decreases expressionISOP2RX6 (Homo sapiens)6480464CTDOzone results in decreased expression of P2RX6 mRNAPMID:23033980
P2rx6multiple interactionsISOP2rx6 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of P2RX6 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of P2RX6 mRNAPMID:27106289 PMID:34911549
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